SrasV1, Main, Exploration, bibRecord, 002112

Genetic Variation of the Human α-2-Heremans-Schmid Glycoprotein (AHSG) Gene Associated with the Risk of SARS-CoV Infection

Identifieur interne : 002112 ( Main/Exploration ); précédent : 002111; suivant : 002113

Genetic Variation of the Human α-2-Heremans-Schmid Glycoprotein (AHSG) Gene Associated with the Risk of SARS-CoV Infection

Source :

PLoS ONE [ 1932-6203 ] ; 2011.

RBID : PMC:3163911

Descripteurs français

KwdFr :
- Adolescent, Adulte, Cellules HepG2, Déséquilibre de liaison (génétique), Femelle, Génotype, Humains, Jeune adulte, Lignée cellulaire, Mâle, Polymorphisme de nucléotide simple (génétique), Régions promotrices (génétique), Syndrome respiratoire aigu sévère (génétique), Syndrome respiratoire aigu sévère (sang), Syndrome respiratoire aigu sévère (virologie), Variation génétique (génétique), Virus du SRAS (pathogénicité), alpha-2-HS-glycoprotéine (génétique), alpha-2-HS-glycoprotéine (métabolisme).
MESH :
- génétique : Déséquilibre de liaison, Polymorphisme de nucléotide simple, Syndrome respiratoire aigu sévère, Variation génétique, alpha-2-HS-glycoprotéine.
- métabolisme : alpha-2-HS-glycoprotéine.
- pathogénicité : Virus du SRAS.
- sang : Syndrome respiratoire aigu sévère.
- virologie : Syndrome respiratoire aigu sévère.
- Adolescent, Adulte, Cellules HepG2, Femelle, Génotype, Humains, Jeune adulte, Lignée cellulaire, Mâle, Régions promotrices (génétique).

English descriptors

KwdEn :
- Adolescent, Adult, Cell Line, Female, Genetic Variation (genetics), Genotype, Hep G2 Cells, Humans, Linkage Disequilibrium (genetics), Male, Polymorphism, Single Nucleotide (genetics), Promoter Regions, Genetic, SARS Virus (pathogenicity), Severe Acute Respiratory Syndrome (blood), Severe Acute Respiratory Syndrome (genetics), Severe Acute Respiratory Syndrome (virology), Young Adult, alpha-2-HS-Glycoprotein (genetics), alpha-2-HS-Glycoprotein (metabolism).
MESH :
- chemical , genetics : alpha-2-HS-Glycoprotein.
- blood : Severe Acute Respiratory Syndrome.
- genetics : Genetic Variation, Linkage Disequilibrium, Polymorphism, Single Nucleotide, Severe Acute Respiratory Syndrome.
- chemical , metabolism : alpha-2-HS-Glycoprotein.
- pathogenicity : SARS Virus.
- virology : Severe Acute Respiratory Syndrome.
- Adolescent, Adult, Cell Line, Female, Genotype, Hep G2 Cells, Humans, Male, Promoter Regions, Genetic, Young Adult.

Abstract

Genetic background may play an important role in the process of SARS-CoV infection and SARS development. We found several proteins that could interact with the nucleocapsid protein of the SARS coronavirus (SARS-CoV). α-2-Heremans-Schmid Glycoprotein (AHSG), which is required for macrophage deactivation by endogenous cations, is associated with inflammatory regulation. Cytochrome P450 Family 3A (CYP4F3A) is an ω-oxidase that inactivates Leukotriene B4 (LTB4) in human neutrophils and the liver. We investigated the association between the polymorphisms of these two inflammation-associated genes and SARS development. The linkage disequilibrium (LD) maps of these two genes were built with Haploview using data on CHB+JPT (version 2) from the HapMap. A total of ten tag SNPs were selected and genotyped. In the Guangzhou cohort study, after adjusting for age and sex, two AHSG SNPs and one CYP4F3 SNP were found to be associated with SARS susceptibility: rs2248690 (adjusted odds ratio [AOR] 2.42; 95% confidence interval [CI] 1.30-4.51); rs4917 (AOR 1.84; 95% CI 1.02-3.34); and rs3794987 (AOR 2.01; 95% CI 1.10–3.68). To further validate the association, the ten tag SNPs were genotyped in the Beijing cohort. After adjusting for age and sex, only rs2248690 (AOR, 1.63; 95% CI, 1.30–2.04) was found to be associated with SARS susceptibility. The combined analysis of the two studies confirmed tag SNP rs2248690 in AHSG as a susceptibility variant (AOR 1.70; 95% CI 1.37–2.09). The statistical analysis of the rs2248690 genotype data among the patients and healthy controls in the HCW cohort, who were all similarly exposed to the SARS virus, also supported the findings. Further, the SNP rs2248690 affected the transcriptional activity of the AHSG promoter and thus regulated the AHSG serum level. Therefore, our study has demonstrated that the AA genotype of rs2268690, which leads to a higher AHSG serum concentration, was significantly associated with protection against SARS development.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163911

DOI: 10.1371/journal.pone.0023730
PubMed: 21904596
PubMed Central: 3163911

Affiliations:

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genetic Variation of the Human α-2-Heremans-Schmid Glycoprotein
(AHSG) Gene Associated with the Risk of SARS-CoV Infection</title>
<author><name sortKey="Zhu, Xiaohui" sort="Zhu, Xiaohui" uniqKey="Zhu X" first="Xiaohui" last="Zhu">Xiaohui Zhu</name>
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<country xml:lang="fr">République populaire de Chine</country>
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<author><name sortKey="Wang, Yan" sort="Wang, Yan" uniqKey="Wang Y" first="Yan" last="Wang">Yan Wang</name>
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</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Pathogen and Bio-Security, Beijing Institute of Biotechnology, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
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<affiliation wicri:level="3"><nlm:aff id="aff5"><addr-line>General Hospital of Beijing Command, PLA, Beijing, China</addr-line>
</nlm:aff>
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<wicri:regionArea>General Hospital of Beijing Command, PLA, Beijing</wicri:regionArea>
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<author><name sortKey="Zhang, Hongxing" sort="Zhang, Hongxing" uniqKey="Zhang H" first="Hongxing" last="Zhang">Hongxing Zhang</name>
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</nlm:aff>
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<author><name sortKey="Liu, Xuan" sort="Liu, Xuan" uniqKey="Liu X" first="Xuan" last="Liu">Xuan Liu</name>
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</nlm:aff>
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<author><name sortKey="Chen, Ting" sort="Chen, Ting" uniqKey="Chen T" first="Ting" last="Chen">Ting Chen</name>
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<author><name sortKey="Yang, Ruifu" sort="Yang, Ruifu" uniqKey="Yang R" first="Ruifu" last="Yang">Ruifu Yang</name>
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<author><name sortKey="Shi, Yuling" sort="Shi, Yuling" uniqKey="Shi Y" first="Yuling" last="Shi">Yuling Shi</name>
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<author><name sortKey="Li, Ping" sort="Li, Ping" uniqKey="Li P" first="Ping" last="Li">Ping Li</name>
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<author><name sortKey="Ma, Qingjun" sort="Ma, Qingjun" uniqKey="Ma Q" first="Qingjun" last="Ma">Qingjun Ma</name>
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</nlm:aff>
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<author><name sortKey="Zhai, Yun" sort="Zhai, Yun" uniqKey="Zhai Y" first="Yun" last="Zhai">Yun Zhai</name>
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</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing</wicri:regionArea>
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</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>National Engineering Research Center for Protein Drugs, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="He, Fuchu" sort="He, Fuchu" uniqKey="He F" first="Fuchu" last="He">Fuchu He</name>
<affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff6"><addr-line>National Engineering Research Center for Protein Drugs, Beijing, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>National Engineering Research Center for Protein Drugs, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhou, Gangqiao" sort="Zhou, Gangqiao" uniqKey="Zhou G" first="Gangqiao" last="Zhou">Gangqiao Zhou</name>
<affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff6"><addr-line>National Engineering Research Center for Protein Drugs, Beijing, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>National Engineering Research Center for Protein Drugs, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cao, Cheng" sort="Cao, Cheng" uniqKey="Cao C" first="Cheng" last="Cao">Cheng Cao</name>
<affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Pathogen and Bio-Security, Beijing Institute of Biotechnology, Beijing, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Pathogen and Bio-Security, Beijing Institute of Biotechnology, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS ONE</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Cell Line</term>
<term>Female</term>
<term>Genetic Variation (genetics)</term>
<term>Genotype</term>
<term>Hep G2 Cells</term>
<term>Humans</term>
<term>Linkage Disequilibrium (genetics)</term>
<term>Male</term>
<term>Polymorphism, Single Nucleotide (genetics)</term>
<term>Promoter Regions, Genetic</term>
<term>SARS Virus (pathogenicity)</term>
<term>Severe Acute Respiratory Syndrome (blood)</term>
<term>Severe Acute Respiratory Syndrome (genetics)</term>
<term>Severe Acute Respiratory Syndrome (virology)</term>
<term>Young Adult</term>
<term>alpha-2-HS-Glycoprotein (genetics)</term>
<term>alpha-2-HS-Glycoprotein (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Cellules HepG2</term>
<term>Déséquilibre de liaison (génétique)</term>
<term>Femelle</term>
<term>Génotype</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Lignée cellulaire</term>
<term>Mâle</term>
<term>Polymorphisme de nucléotide simple (génétique)</term>
<term>Régions promotrices (génétique)</term>
<term>Syndrome respiratoire aigu sévère (génétique)</term>
<term>Syndrome respiratoire aigu sévère (sang)</term>
<term>Syndrome respiratoire aigu sévère (virologie)</term>
<term>Variation génétique (génétique)</term>
<term>Virus du SRAS (pathogénicité)</term>
<term>alpha-2-HS-glycoprotéine (génétique)</term>
<term>alpha-2-HS-glycoprotéine (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>alpha-2-HS-Glycoprotein</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Genetic Variation</term>
<term>Linkage Disequilibrium</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Déséquilibre de liaison</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Variation génétique</term>
<term>alpha-2-HS-glycoprotéine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>alpha-2-HS-Glycoprotein</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>alpha-2-HS-glycoprotéine</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Cell Line</term>
<term>Female</term>
<term>Genotype</term>
<term>Hep G2 Cells</term>
<term>Humans</term>
<term>Male</term>
<term>Promoter Regions, Genetic</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Cellules HepG2</term>
<term>Femelle</term>
<term>Génotype</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Lignée cellulaire</term>
<term>Mâle</term>
<term>Régions promotrices (génétique)</term>
</keywords>
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<front><div type="abstract" xml:lang="en"><p>Genetic background may play an important role in the process of SARS-CoV
infection and SARS development. We found several proteins that could interact
with the nucleocapsid protein of the SARS coronavirus (SARS-CoV).
α-2-Heremans-Schmid Glycoprotein (AHSG), which is required for macrophage
deactivation by endogenous cations, is associated with inflammatory regulation.
Cytochrome P450 Family 3A (CYP4F3A) is an <italic>ω</italic>-oxidase that
inactivates Leukotriene B4 (LTB4) in human neutrophils and the liver. We
investigated the association between the polymorphisms of these two
inflammation-associated genes and SARS development. The linkage disequilibrium
(LD) maps of these two genes were built with Haploview using data on
CHB+JPT (version 2) from the HapMap. A total of ten tag SNPs were selected
and genotyped. In the Guangzhou cohort study, after adjusting for age and sex,
two <italic>AHSG</italic>
 SNPs and one <italic>CYP4F3</italic> SNP were found to
be associated with SARS susceptibility: rs2248690 (adjusted odds ratio
[AOR] 2.42; 95% confidence interval [CI] 1.30-4.51);
rs4917 (AOR 1.84; 95% CI 1.02-3.34); and rs3794987 (AOR 2.01; 95%
CI 1.10–3.68). To further validate the association, the ten tag SNPs were
genotyped in the Beijing cohort. After adjusting for age and sex, only rs2248690
(AOR, 1.63; 95% CI, 1.30–2.04) was found to be associated with SARS
susceptibility. The combined analysis of the two studies confirmed tag SNP
rs2248690 in <italic>AHSG</italic> as a susceptibility variant (AOR 1.70;
95% CI 1.37–2.09). The statistical analysis of the rs2248690
genotype data among the patients and healthy controls in the HCW cohort, who
were all similarly exposed to the SARS virus, also supported the findings.
Further, the SNP rs2248690 affected the transcriptional activity of the
<italic>AHSG</italic> promoter and thus regulated the AHSG serum level.
Therefore, our study has demonstrated that the AA genotype of rs2268690, which
leads to a higher AHSG serum concentration, was significantly associated with
protection against SARS development.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Peiris, Js" uniqKey="Peiris J">JS Peiris</name>
</author>
<author><name sortKey="Lai, St" uniqKey="Lai S">ST Lai</name>
</author>
<author><name sortKey="Poon, Ll" uniqKey="Poon L">LL Poon</name>
</author>
<author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name>
</author>
<author><name sortKey="Yam, Ly" uniqKey="Yam L">LY Yam</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ksiazek, Tg" uniqKey="Ksiazek T">TG Ksiazek</name>
</author>
<author><name sortKey="Erdman, D" uniqKey="Erdman D">D Erdman</name>
</author>
<author><name sortKey="Goldsmith, Cs" uniqKey="Goldsmith C">CS Goldsmith</name>
</author>
<author><name sortKey="Zaki, Sr" uniqKey="Zaki S">SR Zaki</name>
</author>
<author><name sortKey="Peret, T" uniqKey="Peret T">T Peret</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name>
</author>
<author><name sortKey="Gunther, S" uniqKey="Gunther S">S Gunther</name>
</author>
<author><name sortKey="Preiser, W" uniqKey="Preiser W">W Preiser</name>
</author>
<author><name sortKey="Van Der Werf, S" uniqKey="Van Der Werf S">S van der Werf</name>
</author>
<author><name sortKey="Brodt, Hr" uniqKey="Brodt H">HR Brodt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Woo, Pc" uniqKey="Woo P">PC Woo</name>
</author>
<author><name sortKey="Lau, Sk" uniqKey="Lau S">SK Lau</name>
</author>
<author><name sortKey="Tsoi, Hw" uniqKey="Tsoi H">HW Tsoi</name>
</author>
<author><name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name>
</author>
<author><name sortKey="Wong, Bh" uniqKey="Wong B">BH Wong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chang, Wt" uniqKey="Chang W">WT Chang</name>
</author>
<author><name sortKey="Kao, Cl" uniqKey="Kao C">CL Kao</name>
</author>
<author><name sortKey="Chung, My" uniqKey="Chung M">MY Chung</name>
</author>
<author><name sortKey="Chen, Sc" uniqKey="Chen S">SC Chen</name>
</author>
<author><name sortKey="Lin, Sj" uniqKey="Lin S">SJ Lin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, G" uniqKey="Li G">G Li</name>
</author>
<author><name sortKey="Zhao, Z" uniqKey="Zhao Z">Z Zhao</name>
</author>
<author><name sortKey="Chen, L" uniqKey="Chen L">L Chen</name>
</author>
<author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y Zhou</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ho, Ky" uniqKey="Ho K">KY Ho</name>
</author>
<author><name sortKey="Singh, Ks" uniqKey="Singh K">KS Singh</name>
</author>
<author><name sortKey="Habib, Ag" uniqKey="Habib A">AG Habib</name>
</author>
<author><name sortKey="Ong, Bk" uniqKey="Ong B">BK Ong</name>
</author>
<author><name sortKey="Lim, Tk" uniqKey="Lim T">TK Lim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wilder Smith, A" uniqKey="Wilder Smith A">A Wilder-Smith</name>
</author>
<author><name sortKey="Teleman, Md" uniqKey="Teleman M">MD Teleman</name>
</author>
<author><name sortKey="Heng, Bh" uniqKey="Heng B">BH Heng</name>
</author>
<author><name sortKey="Earnest, A" uniqKey="Earnest A">A Earnest</name>
</author>
<author><name sortKey="Ling, Ae" uniqKey="Ling A">AE Ling</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, H" uniqKey="Zhang H">H Zhang</name>
</author>
<author><name sortKey="Zhou, G" uniqKey="Zhou G">G Zhou</name>
</author>
<author><name sortKey="Zhi, L" uniqKey="Zhi L">L Zhi</name>
</author>
<author><name sortKey="Yang, H" uniqKey="Yang H">H Yang</name>
</author>
<author><name sortKey="Zhai, Y" uniqKey="Zhai Y">Y Zhai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ip, Wk" uniqKey="Ip W">WK Ip</name>
</author>
<author><name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name>
</author>
<author><name sortKey="Law, Hk" uniqKey="Law H">HK Law</name>
</author>
<author><name sortKey="Tso, Gh" uniqKey="Tso G">GH Tso</name>
</author>
<author><name sortKey="Kong, Ek" uniqKey="Kong E">EK Kong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ng, Mw" uniqKey="Ng M">MW Ng</name>
</author>
<author><name sortKey="Zhou, G" uniqKey="Zhou G">G Zhou</name>
</author>
<author><name sortKey="Chong, Wp" uniqKey="Chong W">WP Chong</name>
</author>
<author><name sortKey="Lee, Lw" uniqKey="Lee L">LW Lee</name>
</author>
<author><name sortKey="Law, Hk" uniqKey="Law H">HK Law</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chong, Wp" uniqKey="Chong W">WP Chong</name>
</author>
<author><name sortKey="Ip, Wk" uniqKey="Ip W">WK Ip</name>
</author>
<author><name sortKey="Tso, Gh" uniqKey="Tso G">GH Tso</name>
</author>
<author><name sortKey="Ng, Mw" uniqKey="Ng M">MW Ng</name>
</author>
<author><name sortKey="Wong, Wh" uniqKey="Wong W">WH Wong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="He, J" uniqKey="He J">J He</name>
</author>
<author><name sortKey="Feng, D" uniqKey="Feng D">D Feng</name>
</author>
<author><name sortKey="De Vlas, Sj" uniqKey="De Vlas S">SJ de Vlas</name>
</author>
<author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name>
</author>
<author><name sortKey="Fontanet, A" uniqKey="Fontanet A">A Fontanet</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lin, M" uniqKey="Lin M">M Lin</name>
</author>
<author><name sortKey="Tseng, Hk" uniqKey="Tseng H">HK Tseng</name>
</author>
<author><name sortKey="Trejaut, Ja" uniqKey="Trejaut J">JA Trejaut</name>
</author>
<author><name sortKey="Lee, Hl" uniqKey="Lee H">HL Lee</name>
</author>
<author><name sortKey="Loo, Jh" uniqKey="Loo J">JH Loo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ng, Mh" uniqKey="Ng M">MH Ng</name>
</author>
<author><name sortKey="Lau, Km" uniqKey="Lau K">KM Lau</name>
</author>
<author><name sortKey="Li, L" uniqKey="Li L">L Li</name>
</author>
<author><name sortKey="Cheng, Sh" uniqKey="Cheng S">SH Cheng</name>
</author>
<author><name sortKey="Chan, Wy" uniqKey="Chan W">WY Chan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xiong, P" uniqKey="Xiong P">P Xiong</name>
</author>
<author><name sortKey="Zeng, X" uniqKey="Zeng X">X Zeng</name>
</author>
<author><name sortKey="Song, Ms" uniqKey="Song M">MS Song</name>
</author>
<author><name sortKey="Jia, Sw" uniqKey="Jia S">SW Jia</name>
</author>
<author><name sortKey="Zhong, Mh" uniqKey="Zhong M">MH Zhong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chan, Vs" uniqKey="Chan V">VS Chan</name>
</author>
<author><name sortKey="Chan, Ky" uniqKey="Chan K">KY Chan</name>
</author>
<author><name sortKey="Chen, Y" uniqKey="Chen Y">Y Chen</name>
</author>
<author><name sortKey="Poon, Ll" uniqKey="Poon L">LL Poon</name>
</author>
<author><name sortKey="Cheung, An" uniqKey="Cheung A">AN Cheung</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhi, L" uniqKey="Zhi L">L Zhi</name>
</author>
<author><name sortKey="Zhou, G" uniqKey="Zhou G">G Zhou</name>
</author>
<author><name sortKey="Zhang, H" uniqKey="Zhang H">H Zhang</name>
</author>
<author><name sortKey="Zhai, Y" uniqKey="Zhai Y">Y Zhai</name>
</author>
<author><name sortKey="Yang, H" uniqKey="Yang H">H Yang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tang, Nl" uniqKey="Tang N">NL Tang</name>
</author>
<author><name sortKey="Chan, Pk" uniqKey="Chan P">PK Chan</name>
</author>
<author><name sortKey="Hui, Ds" uniqKey="Hui D">DS Hui</name>
</author>
<author><name sortKey="To, Kf" uniqKey="To K">KF To</name>
</author>
<author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Che, Xy" uniqKey="Che X">XY Che</name>
</author>
<author><name sortKey="Hao, W" uniqKey="Hao W">W Hao</name>
</author>
<author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name>
</author>
<author><name sortKey="Di, B" uniqKey="Di B">B Di</name>
</author>
<author><name sortKey="Yin, K" uniqKey="Yin K">K Yin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yasui, F" uniqKey="Yasui F">F Yasui</name>
</author>
<author><name sortKey="Kai, C" uniqKey="Kai C">C Kai</name>
</author>
<author><name sortKey="Kitabatake, M" uniqKey="Kitabatake M">M Kitabatake</name>
</author>
<author><name sortKey="Inoue, S" uniqKey="Inoue S">S Inoue</name>
</author>
<author><name sortKey="Yoneda, M" uniqKey="Yoneda M">M Yoneda</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name>
</author>
<author><name sortKey="Huang, Q" uniqKey="Huang Q">Q Huang</name>
</author>
<author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name>
</author>
<author><name sortKey="Lv, P" uniqKey="Lv P">P Lv</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhu, Ms" uniqKey="Zhu M">MS Zhu</name>
</author>
<author><name sortKey="Pan, Y" uniqKey="Pan Y">Y Pan</name>
</author>
<author><name sortKey="Chen, Hq" uniqKey="Chen H">HQ Chen</name>
</author>
<author><name sortKey="Shen, Y" uniqKey="Shen Y">Y Shen</name>
</author>
<author><name sortKey="Wang, Xc" uniqKey="Wang X">XC Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhou, B" uniqKey="Zhou B">B Zhou</name>
</author>
<author><name sortKey="Liu, J" uniqKey="Liu J">J Liu</name>
</author>
<author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name>
</author>
<author><name sortKey="Liu, X" uniqKey="Liu X">X Liu</name>
</author>
<author><name sortKey="Li, X" uniqKey="Li X">X Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lebreton, Jp" uniqKey="Lebreton J">JP Lebreton</name>
</author>
<author><name sortKey="Joisel, F" uniqKey="Joisel F">F Joisel</name>
</author>
<author><name sortKey="Raoult, Jp" uniqKey="Raoult J">JP Raoult</name>
</author>
<author><name sortKey="Lannuzel, B" uniqKey="Lannuzel B">B Lannuzel</name>
</author>
<author><name sortKey="Rogez, Jp" uniqKey="Rogez J">JP Rogez</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ombrellino, M" uniqKey="Ombrellino M">M Ombrellino</name>
</author>
<author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name>
</author>
<author><name sortKey="Yang, H" uniqKey="Yang H">H Yang</name>
</author>
<author><name sortKey="Zhang, M" uniqKey="Zhang M">M Zhang</name>
</author>
<author><name sortKey="Vishnubhakat, J" uniqKey="Vishnubhakat J">J Vishnubhakat</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W Li</name>
</author>
<author><name sortKey="Zhu, S" uniqKey="Zhu S">S Zhu</name>
</author>
<author><name sortKey="Li, J" uniqKey="Li J">J Li</name>
</author>
<author><name sortKey="Huang, Y" uniqKey="Huang Y">Y Huang</name>
</author>
<author><name sortKey="Zhou, R" uniqKey="Zhou R">R Zhou</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Murphy, Rc" uniqKey="Murphy R">RC Murphy</name>
</author>
<author><name sortKey="Gijon, Ma" uniqKey="Gijon M">MA Gijon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kannan, S" uniqKey="Kannan S">S Kannan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, X" uniqKey="Liu X">X Liu</name>
</author>
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<author><name sortKey="Li, P" uniqKey="Li P">P Li</name>
</author>
<author><name sortKey="Li, L" uniqKey="Li L">L Li</name>
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<author><name sortKey="Yi, Y" uniqKey="Yi Y">Y Yi</name>
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</analytic>
</biblStruct>
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<author><name sortKey="Li, P" uniqKey="Li P">P Li</name>
</author>
<author><name sortKey="Kuang, T" uniqKey="Kuang T">T Kuang</name>
</author>
<author><name sortKey="Li, L" uniqKey="Li L">L Li</name>
</author>
</analytic>
</biblStruct>
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<author><name sortKey="Ohki, T" uniqKey="Ohki T">T Ohki</name>
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<author><name sortKey="Nagasawa, T" uniqKey="Nagasawa T">T Nagasawa</name>
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<author><name sortKey="Suzuki, T" uniqKey="Suzuki T">T Suzuki</name>
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<author><name sortKey="Tian, W" uniqKey="Tian W">W Tian</name>
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<author><name sortKey="Horiuchi, H" uniqKey="Horiuchi H">H Horiuchi</name>
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<author><name sortKey="Kaneko, M" uniqKey="Kaneko M">M Kaneko</name>
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<author><name sortKey="Umetsu, K" uniqKey="Umetsu K">K Umetsu</name>
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<author><name sortKey="Ikeda, Y" uniqKey="Ikeda Y">Y Ikeda</name>
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<author><name sortKey="Suehiro, T" uniqKey="Suehiro T">T Suehiro</name>
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<author><name sortKey="Inada, S" uniqKey="Inada S">S Inada</name>
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<author><name sortKey="Catino, Jj" uniqKey="Catino J">JJ Catino</name>
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<author><name sortKey="Ruley, He" uniqKey="Ruley H">HE Ruley</name>
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<author><name sortKey="Piu, F" uniqKey="Piu F">F Piu</name>
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<author><name sortKey="Szabowski, A" uniqKey="Szabowski A">A Szabowski</name>
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<author><name sortKey="Mohle Steinlein, U" uniqKey="Mohle Steinlein U">U Möhle-Steinlein</name>
</author>
</analytic>
</biblStruct>
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<author><name sortKey="Bianchi, M" uniqKey="Bianchi M">M Bianchi</name>
</author>
<author><name sortKey="Sherry, B" uniqKey="Sherry B">B Sherry</name>
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<author><name sortKey="Sama, A" uniqKey="Sama A">A Sama</name>
</author>
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</biblStruct>
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<author><name sortKey="Cseh, K" uniqKey="Cseh K">K Cseh</name>
</author>
<author><name sortKey="Benedek, S" uniqKey="Benedek S">S Benedek</name>
</author>
<author><name sortKey="Fekete, S" uniqKey="Fekete S">S Fekete</name>
</author>
<author><name sortKey="Masszi, T" uniqKey="Masszi T">T Masszi</name>
</author>
</analytic>
</biblStruct>
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</author>
<author><name sortKey="Kazama, Jj" uniqKey="Kazama J">JJ Kazama</name>
</author>
<author><name sortKey="Wada, Y" uniqKey="Wada Y">Y Wada</name>
</author>
<author><name sortKey="Kuroda, T" uniqKey="Kuroda T">T Kuroda</name>
</author>
<author><name sortKey="Narita, I" uniqKey="Narita I">I Narita</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jezequel, M" uniqKey="Jezequel M">M Jezequel</name>
</author>
<author><name sortKey="Seta, N" uniqKey="Seta N">N Seta</name>
</author>
<author><name sortKey="Corbic, M" uniqKey="Corbic M">M Corbic</name>
</author>
<author><name sortKey="Feger, J" uniqKey="Feger J">J Feger</name>
</author>
<author><name sortKey="Durand, G" uniqKey="Durand G">G Durand</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kalabay, L" uniqKey="Kalabay L">L Kalabay</name>
</author>
<author><name sortKey="Cseh, K" uniqKey="Cseh K">K Cseh</name>
</author>
<author><name sortKey="Pozsonyi, T" uniqKey="Pozsonyi T">T Pozsonyi</name>
</author>
<author><name sortKey="Jakab, L" uniqKey="Jakab L">L Jakab</name>
</author>
<author><name sortKey="Jakab, L" uniqKey="Jakab L">L Jakab</name>
</author>
</analytic>
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</div1>
</back>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
<region><li>Guangdong</li>
</region>
<settlement><li>Jiangmen</li>
<li>Pékin</li>
</settlement>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Zhu, Xiaohui" sort="Zhu, Xiaohui" uniqKey="Zhu X" first="Xiaohui" last="Zhu">Xiaohui Zhu</name>
</noRegion>
<name sortKey="Cao, Cheng" sort="Cao, Cheng" uniqKey="Cao C" first="Cheng" last="Cao">Cheng Cao</name>
<name sortKey="Cao, Wuchun" sort="Cao, Wuchun" uniqKey="Cao W" first="Wuchun" last="Cao">Wuchun Cao</name>
<name sortKey="Chen, Ting" sort="Chen, Ting" uniqKey="Chen T" first="Ting" last="Chen">Ting Chen</name>
<name sortKey="He, Fuchu" sort="He, Fuchu" uniqKey="He F" first="Fuchu" last="He">Fuchu He</name>
<name sortKey="He, Fuchu" sort="He, Fuchu" uniqKey="He F" first="Fuchu" last="He">Fuchu He</name>
<name sortKey="Li, Ping" sort="Li, Ping" uniqKey="Li P" first="Ping" last="Li">Ping Li</name>
<name sortKey="Liu, Xuan" sort="Liu, Xuan" uniqKey="Liu X" first="Xuan" last="Liu">Xuan Liu</name>
<name sortKey="Ma, Qingjun" sort="Ma, Qingjun" uniqKey="Ma Q" first="Qingjun" last="Ma">Qingjun Ma</name>
<name sortKey="Shi, Yuling" sort="Shi, Yuling" uniqKey="Shi Y" first="Yuling" last="Shi">Yuling Shi</name>
<name sortKey="Wang, Yan" sort="Wang, Yan" uniqKey="Wang Y" first="Yan" last="Wang">Yan Wang</name>
<name sortKey="Wang, Yan" sort="Wang, Yan" uniqKey="Wang Y" first="Yan" last="Wang">Yan Wang</name>
<name sortKey="Yang, Ruifu" sort="Yang, Ruifu" uniqKey="Yang R" first="Ruifu" last="Yang">Ruifu Yang</name>
<name sortKey="Zhai, Yun" sort="Zhai, Yun" uniqKey="Zhai Y" first="Yun" last="Zhai">Yun Zhai</name>
<name sortKey="Zhai, Yun" sort="Zhai, Yun" uniqKey="Zhai Y" first="Yun" last="Zhai">Yun Zhai</name>
<name sortKey="Zhang, Hongxing" sort="Zhang, Hongxing" uniqKey="Zhang H" first="Hongxing" last="Zhang">Hongxing Zhang</name>
<name sortKey="Zhang, Hongxing" sort="Zhang, Hongxing" uniqKey="Zhang H" first="Hongxing" last="Zhang">Hongxing Zhang</name>
<name sortKey="Zhou, Gangqiao" sort="Zhou, Gangqiao" uniqKey="Zhou G" first="Gangqiao" last="Zhou">Gangqiao Zhou</name>
<name sortKey="Zhou, Gangqiao" sort="Zhou, Gangqiao" uniqKey="Zhou G" first="Gangqiao" last="Zhou">Gangqiao Zhou</name>
</country>
</tree>
</affiliations>
</record>

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Genetic Variation of the Human α-2-Heremans-Schmid Glycoprotein (AHSG) Gene Associated with the Risk of SARS-CoV Infection

Genetic Variation of the Human α-2-Heremans-Schmid Glycoprotein (AHSG) Gene Associated with the Risk of SARS-CoV Infection

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